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This article is the report by the Yonsei University College of Medicine, from June 1,1959 to October 31, 1966. A total of 88 cases were seen with the following distribution: Hydatidiform mole 44, Cho- rioadenoma destruens 4 and Choriocarcina 40. The following features were noted among the patients with hydatidiform mole. Hydatidiform mole occured once in about 113 precancies and 100 diliversies. Patients ranged in age from 22 to 49 of which majority were between 20-29. The average duration of pregnancies was 3 months. The shortest was 28 days from LMP and longest was 7 months. Toxemia was seen in 36% of patients, of which one case died of eclampsia. All cases of toxemia were occured in those moles in which uterus was elarged above the umbilicus. Half of the patients when first seen had uterine enlargement greater than expected by dates while 20% were consistent with their dates and the rest were smaller than their dates. 28% of the patients developed theca lutein cysts. The vast majority of patients were ma- naged by D & E, while hysterectomies were done in 11.3% and methotrexate therapies in 4.5%. 4.5% of patients developed true malignancies. Choriocarcinoma occured once in about 124 pregnancies and 110 deliveries. Patients with choriocarcin- oma ranged in age from 23 to 62. The average age was 36.40% of patients developed after hydatidiform moles, 37.5% after normal spontaneous vaginal delivery, 20% after abortions, and 2.5% after ectopec pregnancr. 22.5% of patients developed theca lutein cysts. 87.5% of cases showed metastatic lesions those were found in the lung in 70%, vagina in 25%, pelvic and adnexa in 10%, and brain in 7.5% Patients were managed by combined therapies as surgery and chemotherapy with methotrexates in 47.5%, chemotherapies with methotrexates alone in 25%. 17.5% of patients could receive no specific therapy for choriocarcinoma. At present 6 months to 4 years survival rate was 30%, mortality rate was 45% and recurrent rate was 15%.
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